Article
FLT3 mutations: biology and treatment.
Hematology. American Society of Hematology. Education Program - 1 Jan 2006
Small Donald
Abstract excerpt
FLT3 is a receptor tyrosine kinase with important roles in hematopoietic stem/progenitor cell survival and proliferation. It is mutated in about 1/3 of acute myeloid leukemia (AML) patients, either by internal tandem duplications (ITD) of the juxtamembrane domain or by point mutations usually involving the kinase domain (KD). Both types of mutation constitutively activate FLT3. Many studies have shown that AML...
Topics
- Acute Disease
- Antineoplastic Combined Chemotherapy Protocols
- Humans
- Leukemia, Myeloid
- Mutation
- Receptor Protein-Tyrosine Kinases
- fms-Like Tyrosine Kinase 3