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Article

FLT3 mutations: biology and treatment.

Hematology. American Society of Hematology. Education Program - 1 Jan 2006

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Abstract excerpt

FLT3 is a receptor tyrosine kinase with important roles in hematopoietic stem/progenitor cell survival and proliferation. It is mutated in about 1/3 of acute myeloid leukemia (AML) patients, either by internal tandem duplications (ITD) of the juxtamembrane domain or by point mutations usually involving the kinase domain (KD). Both types of mutation constitutively activate FLT3. Many studies have shown that AML...

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Source

Identifiers

PMID: 17124058
DOI: 10.1182/asheducation-2006.1.178

Genes

FLT3
BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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