Article
Serum microRNAs in patients with genetic amyotrophic lateral sclerosis and pre-manifest mutation carriers.
Brain : a journal of neurology - 1 Nov 2014
Freischmidt Axel, Müller Kathrin, Zondler Lisa, Weydt Patrick, Volk Alexander E, Božič Anže Lošdorfer, Walter Michael, Bonin Michael, Mayer Benjamin, von Arnim Christine A F, Otto Markus, Dieterich Christoph, Holzmann Karlheinz, Andersen Peter M, Ludolph Albert C, Danzer Karin M, Weishaupt Jochen H
Abstract excerpt
Knowledge about the nature of pathomolecular alterations preceding onset of symptoms in amyotrophic lateral sclerosis is largely lacking. It could not only pave the way for the discovery of valuable therapeutic targets but might also govern future concepts of pre-manifest disease modifying treatments. MicroRNAs are central regulators of transcriptome plasticity and participate in pathogenic cascades and/or mirror...
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