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Article

Nucleoporin 210 Serves a Key Scaffold for SMARCB1 in Liver Cancer

25 Nov 2020

Abstract excerpt

Abstract The roles of chromatin remodelers and their underlying mechanisms of action in cancer remain unclear. In this study, SMARCB1, known initially as a bona fide tumor suppressor gene, was investigated in liver cancer. SMARCB1 was highly upregulated in patients with liver cancer and was associated with poor prognosis. Loss- and gain-of-function studies in liver cells revealed that SMARCB1 loss led to reduced...

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PMID: 33239431
DOI: 10.1158/0008-5472.can-20-0568

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