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Article

Role of Nonstructural Proteins 3A and 3B in Host Rangeand Pathogenicity of Foot-and-Mouth DiseaseVirus

25 Nov 2003

Abstract excerpt

The genome of foot-and-mouth disease virus (FMDV) differs from that of other picornaviruses in that it encodes a larger 3A protein (>50% longer than poliovirus 3A), as well as three copies of protein 3B (also known as VPg). Previous studies have shown that a deletion of amino acids 93 to 102 of the 153-codon 3A protein is associated with an inability of a Taiwanese strain of FMDV (O/TAW/97) to cause disease in...

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Identifiers

PMID: 14645558
DOI: 10.1128/jvi.77.24.13017-13027.2003

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