Article
Identification of the largest non-essential regions of the C-terminal portion in 3A protein of foot-and-mouth disease virus for replication in cell culture.
Virology journal - 14 Sept 2020
Li Pinghua, Ma Xueqing, Bai Xingwen, Sun Pu, Yuan Hong, Cao Yimei, Li Kun, Bao Huifang, Fu Yuanfang, Zhang Jing, Chen Yingli, Li Dong, Li Zhiyong, Lu Zengjun, Liu Zaixin
Abstract excerpt
BACKGROUND: Recent study has shown that the C-terminal portion of 3A (amino acids (aa) 81-153) is not essential for foot-and-mouth disease virus replication in cell culture, however, the complete C-terminal portion (aa 77-153) of 3A is highly variable and prone to occur deletions and mutations, therefore, we presume that this region plays a very limited role and probablely is completely nonessential for virus...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Line
- Conserved Sequence
- Cricetinae
- Foot-and-Mouth Disease Virus
- Microbial Viability
- Mutation
- Protein Biosynthesis