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Article

Mutation profile and chromosomal abnormality in adenomyosis.

Reproduction (Cambridge, England) - 1 Aug 2025

Suda Kazuaki, Takahashi Kotaro, Tamura Ryo, Saito Kyota, Yamaguchi Manako, Yachida Nozomi, Adachi Sosuke, Kase Hiroaki, Okuda Shujiro, Yoshihara Kosuke, Nakaoka Hirofumi

Abstract excerpt

In brief: By tissue-selective next-generation sequencing, we showed that adenomyotic epithelium harbored genomic alterations thought to be relevant to the development and progression of adenomyosis, including somatic mutations in several cancer-associated genes with high mutant allele frequencies and the gain of chromosome 1q. Clonal relationships among multiple adenomyotic lesions and the normal uterine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40679511
DOI: 10.1530/REP-25-0132
PMCID: PMC12278445

Genes

KRAS
PIK3CA
ARHGAP35
ARID1A

Provenance

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