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Article

HbF-promoting polymorphisms may specifically reduce the residual risk of cerebral vasculopathy in SCA children with alpha-thalassemia.

Clinical hemorheology and microcirculation - 1 Jan 2021

Joly Philippe, Bonello-Palot Nathalie, Badens Catherine, Pissard Serge, Chamouine Abdourahim, Bernaudin Françoise, Bertrand Yves, Connes Philippe, Renoux Céline

Abstract excerpt

Sickle cell anemia (SCA) is a disease characterized by abnormal red blood cell rheology. Because of their effects on HbS polymerization and red blood cell deformability, alpha-thalassemia and the residual HbF level are known genetic modifiers of the disease. The aim of our study was to determine if the number of HbF quantitative trait loci (QTL) would also favor a specific sub-phenotype of SCA as it is the case...

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Identifiers

PMID: 33216016
DOI: 10.3233/CH-200951

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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