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Article

Reduced rate of sickle-related complications in Brazilian patients carrying HbF-promoting alleles at the BCL11A and HMIP-2 loci.

British journal of haematology - 1 May 2016

Leonardo Flávia C, Brugnerotto Ana F, Domingos Igor F, Fertrin Kleber Y, de Albuquerque Dulcinéia M, Bezerra Marcos A C, Araújo Aderson S, Saad Sara T O, Costa Fernando F, Menzel Stephan, Conran Nicola, Thein Swee Lay

Abstract excerpt

The presence of high levels of fetal haemoglobin (HbF) provides well-validated clinical benefits to patients with sickle cell anaemia (SCA). Nevertheless it has been difficult to show clear direct effects of the known genetic HbF modifiers, such as the enhancer polymorphisms for haematopoietic transcription factors BCL11A and MYB, on SCA severity. Investigating SCA patients from Brazil, with a high degree of...

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Share to Anemia, Sickle Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Enhancer Elements, Genetic

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Source

Identifiers

PMID: 26888013
DOI: 10.1111/bjh.13961

Genes

MYB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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