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Article

Speeding up Monte Carlo simulations for the adaptive sum of powered score test with importance sampling.

Biometrics - 1 Mar 2022

Deng Yangqing, He Yinqiu, Xu Gongjun, Pan Wei

Abstract excerpt

A central but challenging problem in genetic studies is to test for (usually weak) associations between a complex trait (e.g., a disease status) and sets of multiple genetic variants. Due to the lack of a uniformly most powerful test, data-adaptive tests, such as the adaptive sum of powered score (aSPU) test, are advantageous in maintaining high power against a wide range of alternatives. However, there is often...

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PMID: 33215683
DOI: 10.1111/biom.13407
PMCID: PMC8134502

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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