High fat diet-induced- and genetically inherited- obesity differential alters DNA demethylation pathways in the germline of adult male rats.

doi:10.1016/j.repbio.2021.100532

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Article

High fat diet-induced- and genetically inherited- obesity differential alters DNA demethylation pathways in the germline of adult male rats.

Reproductive biology - 1 Sept 2021

Deshpande Sharvari S S, Nemani Harishankar, Balasinor Nafisa H

Abstract excerpt

Obesity is a multifactorial condition with predominantly genetic and environmental causes and is an emerging risk factor for male infertility/subfertility. Epigenetic mechanisms are vulnerable to genetic and environmental changes. Our earlier studies have shown differential effects of genetically inherited (GIO) - and diet-induced- obesity (DIO) on DNA methylation in male germline. Contrary to DNA methylation is...

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PMID: 34246869
DOI: 10.1016/j.repbio.2021.100532

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