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Autophagy core protein BECN1 is vital for spermatogenesis and male fertility in mice

17 Nov 2023

Abstract excerpt

Mammalian spermatogenesis is a highly complex multi-step biological process, and autophagy has been demonstrated to be involved in the process of spermatogenesis. Beclin-1/BECN1, a core autophagy factor, plays a critical role in many biological processes and diseases. However, its function in spermatogenesis remains largely unclear. In the present study, germ cell-specific Beclin 1 (Becn1) knockout mice were...

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PMID: 37975917
DOI: 10.1093/biolre/ioad160

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