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Article

CRISPR-Cas9 genome editing using targeted lipid nanoparticles for cancer therapy

19 Nov 2020

Abstract excerpt

(sgPLK1-cLNPs) into aggressive orthotopic glioblastoma enabled up to ~70% gene editing in vivo, which caused tumor cell apoptosis, inhibited tumor growth by 50%, and improved survival by 30%. To reach disseminated tumors, cLNPs were also engineered for antibody-targeted delivery. Intraperitoneal injections of EGFR-targeted sgPLK1-cLNPs caused their selective uptake into disseminated ovarian tumors, enabled up to...

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PMID: 33208369
DOI: 10.1126/sciadv.abc9450

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