Article
BCG-induced trained immunity in NK cells: Role for non-specific protection to infection.
Clinical immunology (Orlando, Fla.) - 1 Dec 2014
Kleinnijenhuis Johanneke, Quintin Jessica, Preijers Frank, Joosten Leo A B, Jacobs Cor, Xavier Ramnik J, van der Meer Jos W M, van Crevel Reinout, Netea Mihai G
Abstract excerpt
Adaptive features of innate immunity, also termed 'trained immunity', have recently been shown to characterize monocytes of BCG vaccinated healthy volunteers. Trained immunity leads to increased cytokine production in response to non-related pathogens via epigenetic reprogramming of monocytes. Recently, memory-like properties were also observed in NK cells during viral infections, but it is unknown if memory...
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