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Article

Association of Oseltamivir Activation with Gender and Carboxylesterase 1 Genetic Polymorphisms.

Basic & clinical pharmacology & toxicology - 1 Dec 2016

Shi Jian, Wang Xinwen, Eyler Rachel F, Liang Yan, Liu Li, Mueller Bruce A, Zhu Hao-Jie

Abstract excerpt

Oseltamivir, an inactive anti-influenza virus prodrug, is activated (hydrolysed) in vivo by carboxylesterase 1 (CES1) to its active metabolite oseltamivir carboxylate. CES1 functions are significantly associated with certain CES1 genetic variants and some non-genetic factors. The purpose of this study was to investigate the effect of gender and several CES1 genetic polymorphisms on oseltamivir activation using a...

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Share to Carboxylic Ester Hydrolases
Share to Gene Expression Regulation, Enzymologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydrolysis

Share to Microsomes, Liver

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Source

Open in PubMed Open full text

Identifiers

PMID: 27228223
DOI: 10.1111/bcpt.12625
PMCID: PMC5118077

Genes

CES1

Variants

rs71647871

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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