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Article

ATF3 Prevents Stress-Induced Hematopoietic Stem Cell Exhaustion

27 Oct 2020

Abstract excerpt

Protection of hematopoietic stem cells (HSCs) from exhaustion and effective regeneration of the HSC pool after bone marrow transplantation or irradiation therapy is an urgent clinical need. Here, we investigated the role of activating transcription factor 3 (ATF3) in steady-state and stress hematopoiesis using conditional knockout mice (Atf3fl/flVav1Cre mice). Deficiency of ATF3 in the hematopoietic system...

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Identifiers

PMID: 33195236
DOI: 10.3389/fcell.2020.585771

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