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Article

Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice

1 Feb 2002

Abstract excerpt

Activating transcription factor (ATF) 4 is a ubiquitous basic leucine-zipper transcription factor that is a member of the ATF/cyclic adenosine monophosphate responsive element-binding (CREB) protein family. To determine the in vivo function of ATF4, the ATF4 gene in murine embryonic stem cells was deleted and homozygous mutant mice were generated. ATF4 null fetuses were severely anemic because of an impairment in...

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PMID: 11806972
DOI: 10.1182/blood.v99.3.736

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