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Article

SCF induces γ-globin gene expression by regulating downstream transcription factor COUP-TFII

28 Apr 2009

Abstract excerpt

Increased fetal hemoglobin expression in adulthood is associated with acute stress erythropoiesis. However, the mechanisms underlying gamma-globin induction during the rapid expansion of adult erythroid progenitor cells have not been fully elucidated. Here, we examined COUP-TFII as a potential repressor of gamma-globin gene after stem cell factor (SCF) stimulation in cultured human adult erythroid progenitor...

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Identifiers

PMID: 19401563
DOI: 10.1182/blood-2008-07-170712

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