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Article

Association of mitochondrial genomic background with risk of Multiple System Atrophy.

Parkinsonism & related disorders - 1 Dec 2020

Valentino Rebecca R, Heckman Michael G, Johnson Patrick W, Soto-Beasley Alexandra I, Walton Ronald L, Koga Shunsuke, Uitti Ryan J, Wszolek Zbigniew K, Dickson Dennis W, Ross Owen A

Abstract excerpt

INTRODUCTION: Multiple system atrophy (MSA) is a rare, sporadic, and progressive neurodegenerative disease which is characterized neuropathologically by alpha-synuclein aggregates in oligodendroglia, and clinically by parkinsonism, ataxia, and autonomic dysfunction. Mitochondrial health influences neurodegeneration and defects in mitochondria, particularly in oxidative phosphorylation, are reported in MSA....

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Identifiers

PMID: 33189969
DOI: 10.1016/j.parkreldis.2020.10.040
PMCID: PMC7769955

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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