Article
HLA-DPB1 and HLA-C alleles are associated with leprosy in a Brazilian population.
Human immunology - 1 Jan 2021
Covolo de Souza-Santana Fabiana, Querino Gislaine Aparecida, Mendes Camargo Rodrigo, Nieto Brito de Souza Vânia, Bettoni Ballallai Mangilli Priscila, Távora Mira Marcelo, Cavalcanti Bezerra Ohanna, Kehdy Fernanda, Laguila Visentainer Jeane Eliete, Alves Hugo Vicentin, Jarduli Luciana Ribeiro, Ozório Moraes Milton, Valin Camarinha Marcos Elaine, Pereira Latini Ana Carla
Abstract excerpt
Despite intense efforts, the number of new cases of leprosy has remained significantly high over the past 20 years. Host genetic background is strongly linked to the pathogenesis of this disease, which is caused by Mycobacterium leprae (M. leprae), and there is a consensus that the most significant genetic association with leprosy is attributed to the major histocompatibility complex (MHC). Here, we investigated...
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