Article
HLA Alleles are Genetic Markers for Susceptibility and Resistance towards Leprosy in a Mexican Mestizo Population.
Annals of human genetics - 1 Jan 2017
Aguilar-Medina Maribel, Escamilla-Tilch Monica, Frías-Castro Luis Octavio, Romero-Quintana Geovanni, Estrada-García Iris, Estrada-Parra Sergio, Granados Julio, Arambula Meraz Eliakym, Sánchez-Schmitz Guzman, Khader Shabaana Abdul, Rangel-Moreno Javier, Ramos-Payán Rosalío
Abstract excerpt
Despite the use of multidrug therapy, leprosy remains endemic in some countries. The association of several human leucocyte antigen (HLA) alleles and gene polymorphisms with leprosy has been demonstrated in many populations, but the major immune contributors associated to the spectrum of leprosy have not been defined yet. In this study, genotyping of HLA-A, -B, -DR, and -DQ alleles was performed in leprosy...
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