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Article

Cumulative health deficits, APOE genotype, and risk for later-life mild cognitive impairment and dementia.

Journal of neurology, neurosurgery, and psychiatry - 1 Feb 2021

Ward David D, Wallace Lindsay M K, Rockwood Kenneth

Abstract excerpt

OBJECTIVE: To determine whether health-deficit accumulation is associated with the risks of mild cognitive impairment (MCI) and dementia independently of APOE genotype. METHODS: A frailty index was calculated using the deficit-accumulation approach in participants aged 50 years and older from the National Alzheimer's Coordinating Center. Cognitive status was determined by clinical evaluation. Using multistate...

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Identifiers

PMID: 33188132
DOI: 10.1136/jnnp-2020-324081
PMCID: PMC7841490

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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