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Article

Up-regulated inflammatory signatures of the spinal cord in canine degenerative myelopathy.

Research in veterinary science - 1 Mar 2021

Hashimoto Kei, Kobatake Yui, Asahina Ryota, Yamato Osamu, Islam Md Shafiqul, Sakai Hiroki, Nishida Hidetaka, Maeda Sadatoshi, Kamishina Hiroaki

Abstract excerpt

Canine degenerative myelopathy (DM) is an adult-onset fatal disease characterized by progressive degeneration of the spinal cord. Affected dogs have homozygous mutations in superoxide dismutase 1, and thus DM is a potential spontaneous animal model of human familial amyotrophic lateral sclerosis (ALS). Neuroinflammation is the pathological hallmark of ALS, whereby proinflammatory cytokines and chemokines are...

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Identifiers

PMID: 33187678
DOI: 10.1016/j.rvsc.2020.11.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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