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Article

Chemokine Profile of Different Inflammatory Myopathies Reflects Humoral versus Cytotoxic Immune Responses

1 Aug 2007

Abstract excerpt

The idiopathic inflammatory myopathies (IM) are subdivided into dermatomyositis (DM), polymyositis (PM), and sporadic inclusion body myositis (IBM). These autoimmune muscle diseases represent different immunopathological entities. DM is a humoral endotheliopathy initiated by complement deposition in intramuscular blood vessels, and characterized by perimysial inflammation and muscle fiber atrophy in...

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PMID: 17785333
DOI: 10.1196/annals.1398.050

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