Article
Characterization of the ExoU activation mechanism using EPR and integrative modeling.
Scientific reports - 12 Nov 2020
Tessmer Maxx H, DeCero Samuel A, Del Alamo Diego, Riegert Molly O, Meiler Jens, Frank Dara W, Feix Jimmy B
Abstract excerpt
ExoU, a type III secreted phospholipase effector of Pseudomonas aeruginosa, serves as a prototype to model large, dynamic, membrane-associated proteins. ExoU is synergistically activated by interactions with membrane lipids and ubiquitin. To dissect the activation mechanism, structural homology was used to identify an unstructured loop of approximately 20 residues in the ExoU amino acid sequence. Mutational...
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