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Article

Complement C6 deficiency exacerbates pathophysiology after spinal cord injury.

Scientific reports - 11 Nov 2020

Su Diane, Hooshmand Mitra J, Galvan Manuel D, Nishi Rebecca A, Cummings Brian J, Anderson Aileen J

Abstract excerpt

Historically, the membrane attack complex, composed of complement components C5b-9, has been connected to lytic cell death and implicated in secondary injury after a CNS insult. However, studies to date have utilized either non-littermate control rat models, or mouse models that lack significant C5b-9 activity. To investigate what role C5b-9 plays in spinal cord injury and recovery, we generated littermate PVG C6...

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Identifiers

PMID: 33177623
DOI: 10.1038/s41598-020-76441-3
PMCID: PMC7659012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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