Article
Human disease-associated genetic variation impacts large intergenic non-coding RNA expression.
PLoS genetics - 1 Jan 2013
Kumar Vinod, Westra Harm-Jan, Karjalainen Juha, Zhernakova Daria V, Esko Tõnu, Hrdlickova Barbara, Almeida Rodrigo, Zhernakova Alexandra, Reinmaa Eva, Võsa Urmo, Hofker Marten H, Fehrmann Rudolf S N, Fu Jingyuan, Withoff Sebo, Metspalu Andres, Franke Lude, Wijmenga Cisca
Abstract excerpt
Recently it has become clear that only a small percentage (7%) of disease-associated single nucleotide polymorphisms (SNPs) are located in protein-coding regions, while the remaining 93% are located in gene regulatory regions or in intergenic regions. Thus, the understanding of how genetic variations control the expression of non-coding RNAs (in a tissue-dependent manner) has far-reaching implications. We tested...
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