Article
Platelet-conditioned media induces an anti-inflammatory macrophage phenotype through EP4.
Journal of thrombosis and haemostasis : JTH - 1 Feb 2021
Heffron Sean P, Weinstock Ada, Scolaro Bianca, Chen Shiyu, Sansbury Brian E, Marecki Greg, Rolling Christina C, El Bannoudi Hanane, Barrett Tessa, Canary James W, Spite Matthew, Berger Jeffrey S, Fisher Edward A
Abstract excerpt
BACKGROUND: Platelets are increasingly recognized as immune cells. As such, they are commonly seen to induce and perpetuate inflammation; however, anti-inflammatory activities are increasingly attributed to them. Atherosclerosis is a chronic inflammatory condition. Similar to other inflammatory conditions, the resolution of atherosclerosis requires a shift in macrophages to an M2 phenotype, enhancing their...
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