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Article

Platelet lysate converts M (IFNγ+LPS) macrophages in CD206+ TGF-β+ arginase+ M2-like macrophages that affect fibroblast activity and T lymphocyte migration.

Journal of tissue engineering and regenerative medicine - 1 Sept 2021

Scopelliti Fernanda, Caterina Cattani, Valentina Dimartino, Gianfranco Costanzo, Concetta Mirisola, Andrea Cavani

Abstract excerpt

Macrophages, thanks to their extreme plasticity, exert critical roles in wound healing by orchestrating tissue defenses in the early inflammatory phase, and by promoting tissue regeneration and angiogenesis at a later time point. In parallel, platelets release a large number of preformed molecules that could affect immunocyte functions. Platelet-rich plasma and platelet lysate (PL) have been widely used as a...

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PMID: 34311512
DOI: 10.1002/term.3229

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