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Article

Secondary CNL after SAA reveals insights in leukemic transformation of bone marrow failure syndromes.

Blood advances - 10 Nov 2020

Schmied Laurent, Olofsen Patricia A, Lundberg Pontus, Tzankov Alexandar, Kleber Martina, Halter Jörg, Uhr Mario, Valk Peter J M, Touw Ivo P, Passweg Jakob, Drexler Beatrice

Abstract excerpt

Acquired aplastic anemia and severe congenital neutropenia (SCN) are bone marrow (BM) failure syndromes of different origin, however, they share a common risk for secondary leukemic transformation. Here, we present a patient with severe aplastic anemia (SAA) evolving to secondary chronic neutrophilic leukemia (CNL; SAA-CNL). We show that SAA-CNL shares multiple somatic driver mutations in CSF3R, RUNX1, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33166403
DOI: 10.1182/bloodadvances.2020001541
PMCID: PMC7656927

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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