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Article

Mechanisms of leukemic transformation in congenital neutropenia

14 Nov 2018

Abstract excerpt

PURPOSE OF REVIEW: The development of a myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) in patients with congenital neutropenia is now the major cause of mortality. Treatment options are limited and there are no effective prevention strategies. This review focuses on mechanisms of leukemic transformation in severe congenital neutropenia (SCN) and Shwachman-Diamond syndrome (SDS), the two most...

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PMID: 30431463
DOI: 10.1097/moh.0000000000000479

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