Article
Sequential gain of mutations in severe congenital neutropenia progressing to acute myeloid leukemia.
Blood - 31 May 2012
Beekman Renée, Valkhof Marijke G, Sanders Mathijs A, van Strien Paulette M H, Haanstra Jurgen R, Broeders Lianne, Geertsma-Kleinekoort Wendy M, Veerman Anjo J P, Valk Peter J M, Verhaak Roel G, Löwenberg Bob, Touw Ivo P
Abstract excerpt
Severe congenital neutropenia (SCN) is a BM failure syndrome with a high risk of progression to acute myeloid leukemia (AML). The underlying genetic changes involved in SCN evolution to AML are largely unknown. We obtained serial hematopoietic samples from an SCN patient who developed AML 17 years after the initiation of G-CSF treatment. Next- generation sequencing was performed to identify mutations during...
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