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Article

Cycloastragenol protects against glucocorticoid‐induced osteogenic differentiation inhibition by activating telomerase

9 Nov 2020

Abstract excerpt

Glucocorticoid-induced osteoporosis (GIOP) that is mainly featured as low bone density and increased risk of fracture is prone to occur with the administration of excessive glucocorticoids. Cycloastragenol (CAG) has been verified to be a small molecule that activates telomerase. Studied showed that up-regulated telomerase was associated with promoting osteogeneic differentiation, so we explored whether CAG could...

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PMID: 33165990
DOI: 10.1002/ptr.6946

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