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Article

Effects of anti-osteoporosis drugs against dexamethasone-induced osteoporosis-like phenotype using a zebrafish scale-regeneration model.

Journal of pharmacological sciences - 1 Jun 2020

Saito Yuichi, Nakamura Shinsuke, Chinen Naoki, Shimazawa Masamitsu, Hara Hideaki

Abstract excerpt

There are several animal models of glucocorticoid-induced osteoporosis (GIOP), but each requires a long time to evaluate drug effects. Zebrafish scales are classified as dermal bone and potentially represent a convenient animal model of GIOP because they rapidly regenerate following their removal. We clarified that dexamethasone-treated regenerating scales showed malformations, decreased size and circularity....

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Identifiers

PMID: 32220570
DOI: 10.1016/j.jphs.2020.02.011

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