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Article

Cortistatin prevents glucocorticoid-associated osteonecrosis of the femoral head via the GHSR1a/Akt pathway

2022-07-01

Abstract excerpt

Long-term use of glucocorticoids (GCs) is known to be a predominant cause of osteonecrosis of the femoral head (ONFH). Moreover, GCs can mediate apoptosis of various cell types by exaggerating oxidative stress. Previous studies have reported that the AKT pathway might be closely associated with apoptosis and metabolism of osteoblasts in ONFH mediated by GCs. We have previously found that cortistatin (CST) antagoni...

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Literature Corpus work
5f6ea402-22bf-51a2-a915-c1a920745baa
DOI
10.21203/rs.3.rs-1727225/v1
Open publication

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Cortistatin prevents glucocorticoid-associated osteonecrosis of the femoral head via the GHSR1a/Akt pathwayDOI 10.21203/rs.3.rs-1727225/v1
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