Article
Silencing of drpr leads to muscle and brain degeneration in adult Drosophila.
The American journal of pathology - 1 Oct 2014
Draper Isabelle, Mahoney Lane J, Mitsuhashi Satomi, Pacak Christina A, Salomon Robert N, Kang Peter B
Abstract excerpt
Mutations in the gene encoding the single transmembrane receptor multiple epidermal growth factor-like domain 10 (MEGF10) cause an autosomal recessive congenital muscle disease in humans. Although mammalian MEGF10 is expressed in the central nervous system as well as in skeletal muscle, patients carrying mutations in MEGF10 do not show symptoms of central nervous system dysfunction. drpr is the sole Drosophila...
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