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Article

Targeting autophagy in ALS: a complex mission.

Autophagy - 1 Apr 2011

Nassif Melissa, Hetz Claudio

Abstract excerpt

Several neurodegenerative diseases share a common neuropathology, primarily featuring the presence of abnormal protein inclusions in the brain containing specific misfolded proteins. Strategies to decrease the load of protein aggregates and oligomers are considered relevant targets for therapeutic intervention. Many studies indicate that macroautophagy is a selective and efficient mechanism for the degradation of...

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PMID: 21252621
DOI: 10.4161/auto.7.4.14700

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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