Article
Structures and functions of mitochondrial ABC transporters.
Biochemical Society transactions - 1 Oct 2015
Schaedler Theresia A, Faust Belinda, Shintre Chitra A, Carpenter Elisabeth P, Srinivasan Vasundara, van Veen Hendrik W, Balk Janneke
Abstract excerpt
A small number of physiologically important ATP-binding cassette (ABC) transporters are found in mitochondria. Most are half transporters of the B group forming homodimers and their topology suggests they function as exporters. The results of mutant studies point towards involvement in iron cofactor biosynthesis. In particular, ABC subfamily B member 7 (ABCB7) and its homologues in yeast and plants are required...
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