Article
MDS-associated SF3B1 mutations enhance proinflammatory gene expression in patient blast cells.
Journal of leukocyte biology - 1 Jul 2021
Pollyea Daniel A, Kim Hyun Min, Stevens Brett M, Lee Frank Fang-Yao, Harris Chelsea, Hedin Brenna R, Knapp Jennifer R, O'Connor Brian P, Jordan Craig T, Pietras Eric M, Tan Aik Choon, Alper Scott
Abstract excerpt
Two factors known to contribute to the development of myelodysplastic syndrome (MDS) and other blood cancers are (i) somatically acquired mutations in components of the spliceosome and (ii) increased inflammation. Spliceosome genes, including SF3B1, are mutated at high frequency in MDS and other blood cancers; these mutations are thought to be neomorphic or gain-of-function mutations that drive disease...
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