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Article

Azathioprine dose tailoring based on pharmacogenetic information: Insights of clinical implementation.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Dec 2023

Díaz-Villamarín Xando, Fernández-Varón Emilio, Rojas Romero Michelle Carolina, Callejas-Rubio José Luis, Cabeza-Barrera José, Rodríguez-Nogales Alba, Gálvez Julio, Morón Rocío

Abstract excerpt

Azathioprine is commonly used as an immunosuppressive antimetabolite in the treatment of acute lymphoblastic leukemia, autoimmune disorders (such as Crohn's disease and rheumatoid arthritis), and in patients receiving organ transplants. Thiopurine-S-methyltransferase (TPMT) is a cytoplasmic trans-methylase catalyzing the S-methylation of thiopurines. The active metabolites obtained from thiopurines are hydrolyzed...

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Identifiers

PMID: 37857254
DOI: 10.1016/j.biopha.2023.115706

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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