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Generation and maturation of human iPSC-derived 3D organotypic cardiac microtissues in long-term culture

18 Oct 2022

Abstract excerpt

Cardiovascular diseases remain the leading cause of death worldwide; hence there is an increasing focus on developing physiologically relevant in vitro cardiovascular tissue models suitable for studying personalized medicine and pre-clinical tests. Despite recent advances, models that reproduce both tissue complexity and maturation are still limited. We have established a scaffold-free protocol to generate...

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PMID: 36257968
DOI: 10.1038/s41598-022-22225-w

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