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Article

Aortic calcified particles modulate valvular endothelial and interstitial cells.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology - 1 Jan 2000

van Engeland Nicole C A, Bertazzo Sergio, Sarathchandra Padmini, McCormack Ann, Bouten Carlijn V C, Yacoub Magdi H, Chester Adrian H, Latif Najma

Abstract excerpt

BACKGROUND: Normal and calcified human valve cusps, coronary arteries, and aortae harbor spherical calcium phosphate microparticles of identical composition and crystallinity, and their role remains unknown. OBJECTIVE: The objective was to examine the direct effects of isolated calcified particles on human valvular cells. METHOD AND RESULTS: Calcified particles were isolated from healthy and diseased aortae,...

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Identifiers

PMID: 28319833
DOI: 10.1016/j.carpath.2017.02.006

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