Intra-host non-synonymous diversity at a neutralizing antibody epitope of SARS-CoV-2 spike protein N-terminal domain.

doi:10.1016/j.cmi.2020.10.030

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Article

Intra-host non-synonymous diversity at a neutralizing antibody epitope of SARS-CoV-2 spike protein N-terminal domain.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases - 1 Sept 2021

Ip Jonathan Daniel, Kok Kin-Hang, Chan Wan-Mui, Chu Allen Wing-Ho, Wu Wai-Lan, Yip Cyril Chik-Yan, To Wing-Kin, Tsang Owen Tak-Yin, Leung Wai-Shing, Chik Thomas Shiu-Hong, Chan Kwok-Hung, Hung Ivan Fan-Ngai, Yuen Kwok-Yung, To Kelvin Kai-Wang

Abstract excerpt

OBJECTIVES: SARS-CoV-2 has evolved rapidly into several genetic clusters. However, data on mutations during the course of infection are scarce. This study aims to determine viral genome diversity in serial samples of COVID-19 patients. METHODS: Targeted deep sequencing of the spike gene was performed on serial respiratory specimens from COVID-19 patients using nanopore and Illumina sequencing. Sanger sequencing...

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Identifiers

PMID: 33144203
DOI: 10.1016/j.cmi.2020.10.030
PMCID: PMC7605743

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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