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Article

Dissecting Naturally Arising Amino Acid Substitutions at Position L452 of SARS-CoV-2 Spike.

Journal of virology - 26 Oct 2022

Tan Toong Seng, Toyoda Mako, Ode Hirotaka, Barabona Godfrey, Hamana Hiroshi, Kitamatsu Mizuki, Kishi Hiroyuki, Motozono Chihiro, Iwatani Yasumasa, Ueno Takamasa

Abstract excerpt

Mutations at spike protein L452 are recurrently observed in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOC), including omicron lineages. It remains elusive how amino acid substitutions at L452 are selected in VOC. Here, we characterized all 19 possible mutations at this site and revealed that five mutants expressing the amino acids Q, K, H, M, and R gained greater...

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Amino Acid Substitution
Amino Acids
COVID-19
Immune Sera
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Spike Glycoprotein, Coronavirus

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Identifiers

PMID: 36214577
DOI: 10.1128/jvi.01162-22
PMCID: PMC9599599

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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