Article
Genotype-Based Gene Expression in Colon Tissue-Prediction Accuracy and Relationship with the Prognosis of Colorectal Cancer Patients.
International journal of molecular sciences - 31 Oct 2020
Deutelmoser Heike, Lorenzo Bermejo Justo, Benner Axel, Weigl Korbinian, Park Hanla A, Haffa Mariam, Herpel Esther, Schneider Martin, Ulrich Cornelia M, Hoffmeister Michael, Chang-Claude Jenny, Brenner Hermann, Scherer Dominique
Abstract excerpt
Colorectal cancer (CRC) survival has environmental and inherited components. The expression of specific genes can be inferred based on individual genotypes-so called expression quantitative trait loci. In this study, we used the PrediXcan method to predict gene expression in normal colon tissue using individual genotype data from 91 CRC patients and examined the correlation ρ between predicted and measured gene...
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