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Article

Does height and IGF-I determine pubertal timing in girls?

Pediatric research - 1 Jul 2021

Upners Emmie N, Busch Alexander S, Almstrup Kristian, Petersen Jørgen H, Assens Maria, Main Katharina M, Jensen Rikke B, Juul Anders

Abstract excerpt

BACKGROUND: Pubertal timing is closely linked to growth regulated by the growth hormone/insulin-like factor (GH/IGF) axis that includes IGF-regulating factors such as pregnancy-associated plasma protein-A/A2 (PAPP-A/PAPP-A2) and stanniocalcin 2 (STC2). We investigated the association between height, IGF-I concentration, and PAPPA, PAPPA2, and STC2 genotypes on the timing of female pubertal milestones. METHODS:...

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Identifiers

PMID: 33142306
DOI: 10.1038/s41390-020-01215-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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