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Article

A double-stranded DNA catalyzed strand displacement system for detection of small genetic variations.

Chemical communications (Cambridge, England) - 19 Nov 2020

Liu Na, Zhang Xuzhe, Tang Xiaofeng, Liu Yizhou, Huang Donghui, Xiao Xianjin

Abstract excerpt

A double-stranded DNA catalyzed strand displacement system (dsCSD) was established for the detection of small genetic variations, which showed greatly enhanced specificity compared to the conventional single-stranded DNA catalyzed strand displacement (ssCSD) system. The system achieved limits of detection (LODs) of 0.05% and 0.1% for synthesized DNA samples and clinical gene samples, respectively.

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Identifiers

PMID: 33140767
DOI: 10.1039/d0cc06216b

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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