Article
Transcriptomic responses from improved murine sepsis models can better mimic human surgical sepsis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2021
Efron Philip A, Darden Dijoia B, Wang Zhongkai, Nacionales Dina C, Lopez Maria-Cecilia, Hawkins Russell B, Cox Michael C, Rincon Jaimar C, Ungaro Ricardo, Dirain Marvin L, Ghita Gabriela L, Chen Tianmeng, Billiar Timothy R, Delano Matthew J, Leeuwenburgh Christiaan, Bihorac Azra, Brakenridge Scott C, Moore Frederick A, Mohr Alicia M, Tompkins Ronald G, Brumback Babette A, Baker Henry V, Upchurch Gilbert R, Moldawer Lyle L
Abstract excerpt
Historically, murine models of inflammation in biomedical research have been shown to minimally correlate with genomic expression patterns from blood leukocytes in humans. In 2019, our laboratory reported an improved surgical sepsis model of cecal ligation and puncture (CLP) that provides additional daily chronic stress (DCS), as well as adhering to the Minimum Quality Threshold in Pre-Clinical Sepsis Studies...
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