Article

Applying Transcriptomics for an Enhanced Clinical Research Framework, Implications for an Improved Research Strategy based on an Omics Approach: A Scoping Review

2022-10-07

Abstract excerpt

Sepsis remains a major global health issue in pediatric and adult populations, largely due to a lack of understanding of its complex pathophysiology. Despite its high mortality rate, there have been few advancements in sepsis-specific therapies over recent decades. The study aimed to investigate the potential benefits of a genome-wide transcriptomic approach to sepsis in pediatric and adult populations in reducing...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e52b9ba7-8c11-5c31-b54c-9f0e94b2701f
DOI: 10.1101/2022.10.05.22280692

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Applying Transcriptomics for an Enhanced Clinical Research Framework, Implications for an Improved Research Strategy based on an Omics Approach: A Scoping ReviewDOI 10.1101/2022.10.05.22280692Read

Advancing sepsis clinical research: harnessing transcriptomics for an omics-based strategy - a comprehensive scoping reviewSemantic proximity Read

Multilevel omics for the discovery of biomarkers in pediatric sepsisSemantic proximity Read

A Transcriptomic Severity Metric that Predicts Clinical Outcomes in Critically Ill Surgical Sepsis PatientsSemantic proximity Read

Unique transcriptomic response to sepsis is observed among patients of different age groupsSemantic proximity Read

Landscape of multiple tissues' gene expression pattern associated with severe sepsis: Genetic insights from Mendelian randomization and trans-omics analysis.Semantic proximity Read

Proteomics Combined with RNA Sequencing to Screen Biomarkers of SepsisSemantic proximity Read

Unsupervised Analysis of Transcriptomics in Bacterial Sepsis Across Multiple Datasets Reveals Three Robust ClustersSemantic proximity Read

Defining critical illness using immunological endotypes in patients with and without of sepsis: A cohort studySemantic proximity Read

Screening of Key Genes of Sepsis and Septic Shock Using Bioinformatics AnalysisSemantic proximity Read

Transcriptomic Profiles of Sepsis in the Human BrainSemantic proximity Read

Predicting severity in COVID-19 disease using sepsis blood gene expression signaturesSemantic proximity Read

An integrated transcriptome and expressed variant analysis of sepsis survival and deathSemantic proximity Read