Article
High Potency of a Bivalent Human VH Domain in SARS-CoV-2 Animal Models.
Cell - 15 Oct 2020
Li Wei, Schäfer Alexandra, Kulkarni Swarali S, Liu Xianglei, Martinez David R, Chen Chuan, Sun Zehua, Leist Sarah R, Drelich Aleksandra, Zhang Liyong, Ura Marcin L, Berezuk Alison, Chittori Sagar, Leopold Karoline, Mannar Dhiraj, Srivastava Shanti S, Zhu Xing, Peterson Eric C, Tseng Chien-Te, Mellors John W, Falzarano Darryl, Subramaniam Sriram, Baric Ralph S, Dimitrov Dimiter S
Abstract excerpt
Novel COVID-19 therapeutics are urgently needed. We generated a phage-displayed human antibody VH domain library from which we identified a high-affinity VH binder ab8. Bivalent VH, VH-Fc ab8, bound with high avidity to membrane-associated S glycoprotein and to mutants found in patients. It potently neutralized mouse-adapted SARS-CoV-2 in wild-type mice at a dose as low as 2 mg/kg and exhibited high prophylactic...
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