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Article

Aggregation dynamics and identification of aggregation-prone mutants of the von Hippel-Lindau tumor suppressor protein.

Journal of cell science - 1 Jul 2016

Le Goff Xavier, Chesnel Franck, Delalande Olivier, Couturier Anne, Dréano Stéphane, Le Goff Cathy, Vigneau Cécile, Arlot-Bonnemains Yannick

Abstract excerpt

Quality control mechanisms promote aggregation and degradation of misfolded proteins. In budding yeast, the human von Hippel-Lindau protein (pVHL, officially known as VHL) is misfolded and forms aggregates. Here, we investigated the aggregation of three pVHL isoforms (pVHL213, pVHL160, pVHL172) in fission yeast. The full-length pVHL213 isoform aggregates in highly dynamic small puncta and in large spherical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27179072
DOI: 10.1242/jcs.184846

Genes

VHL

Provenance

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